In vivo noninvasive measurement of spatially resolved corneal elasticity in human eyes using Lamb wave optical coherence elastography

• Published in: Journal of biophotonics Vol. 13; no. 8; pp. e202000104 - n/a
• Main Authors: Jin, Zi, Chen, Sisi, Dai, Yingying, Bao, Chenhong, Ye, Shuling, Zhou, Yuheng, Wang, Yiyi, Huang, Shenghai, Wang, Yuanyuan, Shen, Meixiao, Zhu, Dexi, Lu, Fan
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.08.2020; Wiley Subscription Services, Inc
• Subjects: air‐puff optical coherence elastography; Algorithms; Coherence; Cornea; Dispersion curve analysis; Elasticity; Eye; Eye (anatomy); eye motion artifact correction; human corneal elasticity; in vivo imaging; Intraocular pressure; Lamb wave; Lamb waves; Phase velocity; Wave propagation; Lamb wave; human corneal elasticity; air-puff optical coherence elastography; in vivo imaging; eye motion artifact correction
• ISSN: 1864-063X; 1864-0648; 1864-0648
• DOI: 10.1002/jbio.202000104

Current elastography techniques are limited in application to accurately assess spatially resolved corneal elasticity in vivo for human eyes. The air‐puff optical coherence elastography (OCE) with an eye motion artifacts correction algorithm is developed to distinguish the in vivo cornea vibration from the eye motion and visualize the Lamb wave propagation clearly in healthy subjects. Based on the Lamb wave model, the phase velocity dispersion curve in the high‐frequency is calculated to obtain spatially resolved corneal elasticity accurately with high repeatability. It is found that the corneal elasticity has regional variations and is correlated with intraocular pressure, which suggests that the method has the potential to provide noninvasive measurement of spatially resolved corneal elasticity in clinical practice. The air‐puff OCE with an eye motion artifacts correction algorithm is developed to measure the human corneal elasticity noninvasively. The physiological and air‐puff induced axial eye motion artifacts are corrected by deaverage of the corneal spatial‐temporal Doppler phase images in time, and space domain respectively. Using the Lamb wave model, the phase velocity dispersion curve in the high‐frequency is calculated to obtain corneal elasticity accurately with high repeatability.