The Discovery and Anti‐Colorectal Cancer Activities of Cembranolides from the South China Sea Soft Coral Sinularia pendunculata

A new cembranolide, namely, sinupendunculide A (1), along with eight known related compounds (2–9), was isolated from the South China Sea Soft coral Sinularia pendunculata. The structure of sinupendunculide A (1) was established by extensive spectroscopic analysis and X‐ray diffraction experiments....

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Published inChemistry & biodiversity Vol. 20; no. 4; pp. e202300214 - n/a
Main Authors Wang, Hong‐Ru, Jin, Yang, Sun, Ruo‐Nan, Yao, Li‐Gong, Xia, Jian‐Hua, Huang, Yun, Liu, San‐Hong, Zhang, Wei‐Dong, Li, Xu‐Wen
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.04.2023
Subjects
Animals
Anthozoa - chemistry
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
antitumor
Apoptosis
Bioassays
Cancer
cell apoptosis
Cell proliferation
cembranolide
China
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - prevention & control
Cytotoxicity
Diterpenes - chemistry
Diterpenes - pharmacology
marine natural products
Molecular Structure
Neoplasms
Reactive oxygen species
Sinularia
Sinularia penduculata
Toxicity
China
cell apoptosis
marine natural products
antitumor
cembranolide
Sinularia penduculata
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Summary:A new cembranolide, namely, sinupendunculide A (1), along with eight known related compounds (2–9), was isolated from the South China Sea Soft coral Sinularia pendunculata. The structure of sinupendunculide A (1) was established by extensive spectroscopic analysis and X‐ray diffraction experiments. In a bioassay, anti‐colorectal cancer (CRC) activity was performed, and the results showed that several compounds exhibited cytotoxicity against RKO cells, and a preliminary structure‐activity relationship was analysed. Meanwhile, the most effective compound 7 was proven to increase reactive oxygen species levels, which promoted cell apoptosis and inhibited cell proliferation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300214