Photothermal‐Controllable Microneedles with Antitumor, Antioxidant, Angiogenic, and Chondrogenic Activities to Sequential Eliminate Tracheal Neoplasm and Reconstruct Tracheal Cartilage

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 20; no. 11; pp. e2309454 - n/a
• Main Authors: Wang, B., Fei, X., Yin, H. F., Xu, X. N., Zhu, J. J., Guo, Z. Y., Wu, J. W., Zhu, X. S., Zhang, Y., Xu, Y., Yang, Y., Chen, L. S.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2024
• Subjects: Anhydrides; Antioxidants; Cartilage; cartilage regeneration; Controllability; Copper; Hydrogels; Manganese dioxide; multifunctional microneedle; Nanosheets; Needles; Overheating; photothermal‐controllable; Scavenging; sequential treatment; Stem cells; tracheal neoplasms; Tumors; sequential treatment; photothermal-controllable; cartilage regeneration; multifunctional microneedle; tracheal neoplasms
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.202309454

The optimal treatment for tracheal tumors necessitates sequential tumor elimination and tracheal cartilage reconstruction. This study introduces an innovative inorganic nanosheet, MnO2/PDA@Cu, comprising manganese dioxide (MnO2) loaded with copper ions (Cu) through in situ polymerization using polydopamine (PDA) as an intermediary. Additionally, a specialized methacrylic anhydride modified decellularized cartilage matrix (MDC) hydrogel with chondrogenic effects is developed by modifying a decellularized cartilage matrix with methacrylic anhydride. The MnO2/PDA@Cu nanosheet is encapsulated within MDC‐derived microneedles, creating a photothermal‐controllable MnO2/PDA@Cu‐MDC microneedle. Effectiveness evaluation involved deep insertion of the MnO2/PDA@Cu‐MDC microneedle into tracheal orthotopic tumor in a murine model. Under 808 nm near‐infrared irradiation, facilitated by PDA, the microneedle exhibited rapid overheating, efficiently eliminating tumors. PDA's photothermal effects triggered controlled MnO2 and Cu release. The MnO2 nanosheet acted as a potent inorganic nanoenzyme, scavenging reactive oxygen species for an antioxidant effect, while Cu facilitated angiogenesis. This intervention enhanced blood supply at the tumor excision site, promoting stem cell enrichment and nutrient provision. The MDC hydrogel played a pivotal role in creating a chondrogenic niche, fostering stem cells to secrete cartilaginous matrix. In conclusion, the MnO2/PDA@Cu‐MDC microneedle is a versatile platform with photothermal control, sequentially combining antitumor, antioxidant, pro‐angiogenic, and chondrogenic activities to orchestrate precise tracheal tumor eradication and cartilage regeneration. The figure showcases the intricate design of the MnO2/PDA@Cu‐MDC microneedle, illustrating its composite structure and the mechanism of action within the tracheal orthotopic tumor. A graphic representation highlights the nanosheet's multifunctionality, demonstrating the controlled release of MnO2 and Cu upon near‐infrared irradiation, fostering angiogenesis and facilitating cartilage regeneration amidst tumor eradication.