Optical Biosensors for Detection of Cancer Biomarkers: Current and Future Perspectives

• Published in: Journal of biophotonics Vol. 17; no. 12; pp. e202400243 - n/a
• Main Authors: Moorthy, Dharsini Narayana, Dhinasekaran, Durgalakshmi, Rebecca, P. N. Blessy, Rajendran, Ajay Rakkesh
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.12.2024; Wiley Subscription Services, Inc
• Subjects: Biomarkers; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Biosensing Techniques - instrumentation; Biosensors; Cancer; Colorimetry; Diagnosis; disease diagnosis; Energy transfer; Fluorescence resonance energy transfer; fluorescence‐based sensing; FTIR; Humans; label‐free detection; Microfluidics; Nanomaterials; Nanoparticles; Nanotechnology; Neoplasms - diagnosis; Neoplasms - diagnostic imaging; optical biosensors; Optical measuring instruments; Optical Phenomena; Raman spectroscopy; Resonance; Sensitivity analysis; Spectrum Analysis, Raman - instrumentation; Surface plasmon resonance; wearable biosensors; wearable biosensors; label‐free detection; surface plasmon resonance; FTIR; fluorescence‐based sensing; disease diagnosis; microfluidics; optical biosensors
• ISSN: 1864-063X; 1864-0648; 1864-0648
• DOI: 10.1002/jbio.202400243

ABSTRACT Optical biosensors are emerging as a promising technique for the sensitive and accurate detection of cancer biomarkers, enabling significant advancements in the field of early diagnosis. This study elaborates on the latest developments in optical biosensors designed for detecting cancer biomarkers, highlighting their vital significance in early cancer diagnosis. When combined with targeted nanoparticles, the bio‐fluids can help in the molecular stage diagnosis of cancer. This enhances the discrimination of disease from the normal subjects drastically. The optical sensor methods that are involved in the disease diagnosis and imaging of cancer taken for the present review are surface plasmon resonance, localized surface plasmon resonance, fluorescence resonance energy transfer, surface‐enhanced Raman spectroscopy and colorimetric sensing. The article meticulously describes the specific biomarkers and analytes that optical biosensors target. Beyond elucidating the underlying principles and applications, this article furnishes an overview of recent breakthroughs and emerging trends in the field. This encompasses the evolution of innovative nanomaterials and nanostructures designed to augment sensitivity and the incorporation of microfluidics for facilitating point‐of‐care testing, thereby charting a course towards prospective advancements. Advance early cancer diagnosis through optical biosensors to improve sensitivity, accuracy and point‐of‐care detection.