Anti‐Inflammatory Phomalones from the Deep‐Sea‐Derived Fungus Trichobotrys effuse FS522

Four new phomalones A−D (1–4), together with five known analogues (5–9) were isolated from the deep‐sea‐derived fungus Trichobotrys effuse FS522. Their structures of the new compounds established by analysis of their NMR and HR‐ESI‐MS spectroscopic data, and the absolute configurations of 2 was dete...

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Published inChemistry & biodiversity Vol. 20; no. 12; pp. e202301512 - n/a
Main Authors Huang, Hui‐Bin, Chen, Yu‐Chan, Wen, Ting‐Yue, Li, Sai‐Ni, Liu, Zhao‐Ming, Zhang, Wei‐Min, Gao, Xiao‐Xia
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.12.2023
Subjects
anti-inflammatory
Anti-Inflammatory Agents - pharmacology
Ascomycota
Circular dichroism
deep-sea-derived fungus
Dichroism
Fungi
Heterocyclic Compounds, 3-Ring - chemistry
Heterocyclic Compounds, 3-Ring - pharmacology
Inflammation
Magnetic Resonance Spectroscopy - methods
Molecular Structure
Nitric oxide
NMR
Nuclear magnetic resonance
phomalones
Pyrans - chemistry
Pyrans - pharmacology
spectroscopic analysis
Trichobotrys effuse
anti-inflammatory
spectroscopic analysis
phomalones
Trichobotrys effuse
deep-sea-derived fungus
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Summary:Four new phomalones A−D (1–4), together with five known analogues (5–9) were isolated from the deep‐sea‐derived fungus Trichobotrys effuse FS522. Their structures of the new compounds established by analysis of their NMR and HR‐ESI‐MS spectroscopic data, and the absolute configurations of 2 was determined by electronic circular dichroism (ECD) calculations. compounds 4, 6 and 8 substantially inhibited the production of nitric oxide (NO) with IC50 values of 4.64, 13.90, and 34.07 μM.
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ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202301512