Combination of PEG‐b‐PAA Carrier and Efficient Cationic Photosensitizers for Photodynamic Therapy

• Published in: Chemistry, an Asian journal Vol. 18; no. 10; pp. e202300212 - n/a
• Main Authors: Yang, Hui, Shang, Zhanhao, Shi, Qiankun, Gao, Jucai, Wang, Xiaorui, Hu, Fang
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 16.05.2023
• Subjects: Acrylic resins; aggregation-induced emission; Block copolymers; cancer therapy; Cations; Chemistry; efficient PDT; Humans; Ionic interactions; Nanoparticles; Nanoparticles - chemistry; Neoplasms - drug therapy; Photochemotherapy - methods; Photodynamic therapy; photosensitizers; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; Polyethylene glycol; Polyethylene Glycols - chemistry; Polymers - chemistry; Reactive Oxygen Species; Self-assemble; aggregation-induced emission; cancer therapy; photosensitizers; Self-assemble; efficient PDT
• ISSN: 1861-4728; 1861-471X
• DOI: 10.1002/asia.202300212

Photodynamic therapy (PDT) is recognized to be a promising strategy for anticancer treatment. Considering the progressive application of PDT in clinical trials, highly efficient photosensitizers (PSs) are in strong demand. Aggregation‐induced emission (AIE) based PSs are promising phototheranostic materials for tumor imaging and PDT due to their high fluorescence and photosensitizing efficiency. Herein, a PS, TPA‐2BCP with AIE characteristics is developed by adopting an acceptor‐π‐donor‐π‐acceptor (A–π–D–π–A) structure. However, the accumulation of ionic PSs in the tumor is poor due to non‐specific interactions with bio‐molecules. Therefore, we use a carboxyl‐rich polymer material, polyacrylate polyethylene glycol block copolymer (PEG‐b‐PAA) to encapsulate the cationic PSs into nanoparticles through ionic interactions. The cationic groups are blocked and the generated PS nanoparticles can accumulate well in the tumor site in vivo. Meanwhile, the photosensitizing efficiency of the PS is further enhanced in the nanoparticle format. The tumor growth can be obviously inhibited under 530 nm laser irradiation, demonstrating its potential application in antitumor PDT. The A–π–D–π–A structure is a better formulation than D–π–A structure to design aggregation‐induced emission photosensitizers (AIE PSs). By further introducing carboxyl‐rich PEG‐b‐PAA as a carrier to shield the ionic interaction between the two cationic electron‐accepting groups and bio‐molecules, the generated nanoparticles can accumulate in tumor well and undergo photodynamic therapy efficiently.