Recent Progress and Perspectives on Cell Surface Modification

The cell membrane is a biological interface consisting of phospholipid bilayer, saccharides and proteins that maintains a stable metabolic intracellular environment as well as regulating and controlling the exchange of substances inside and outside the cell. Cell membranes provide a highly complex b...

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Published inChemistry, an Asian journal Vol. 16; no. 21; pp. 3250 - 3258
Main Authors Zhang, Shi‐Yi, Zhou, Ze‐Rui, Qian, Ruo‐Can
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 02.11.2021
Subjects
Carbohydrates
Cell Membrane - chemistry
Cell Membrane - metabolism
cell membrane strain
Cell membranes
Cell surface modification
Chemistry
DNAzyme
Glycan modification
Humans
Phospholipids
Receptors
Surface Properties
DNAzyme
Glycan modification
cell membrane strain
Cell surface modification
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Summary:The cell membrane is a biological interface consisting of phospholipid bilayer, saccharides and proteins that maintains a stable metabolic intracellular environment as well as regulating and controlling the exchange of substances inside and outside the cell. Cell membranes provide a highly complex biological surface carrying a variety of essential surfaces ligands and receptors for cells to receive various stimuli of external signals, thereby inducing corresponding cell responses regulating the life activities of the cell. These surface receptors can be manipulated via cell surface modification to regulate cellular functions and behaviors Thus, cell surface modification has attracted considerable attention due to its significance in cell fate control, cell engineering and cell therapy. In this minireview, we describe the recent developments and advances of cell surface modification, and summarize the main modification methods with corresponding functions and applications. Finally, the prospect for the future development of the modification of the living cell membrane is discussed. The recent developments and advances of cell surface modification were well discussed, including the main modification methods with corresponding functions and applications. The prospect for the future development of the modification of the living cell membrane is mentioned as well.
Bibliography:These authors contributed equally to this work.
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ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202100852