Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with a multitude of pharmacological activities. The primary emphasis of this study is on summarizing the anticancer properties with the underlying mechanisms of RA and its derivatives, as well as the pharmacokinetic features. Data wa...

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Published inChemistry & biodiversity Vol. 21; no. 2; pp. e202301492 - n/a
Main Authors Bhuia, Md. Shimul, Chowdhury, Raihan, Sonia, Fatema Akter, Biswas, Shrabonti, Ferdous, Jannatul, El‐Nashar, Heba A. S., El‐Shazly, Mohamed, Islam, Muhammad Torequl
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.02.2024
Subjects
Angiogenesis
Anticancer properties
Apoptosis
Cancer
Cell cycle
Cell death
Cell migration
Cervical cancer
Cytotoxicity
Inflammation
Oxidative stress
Pharmacokinetics
Pharmacology
rotundic acid
Search engines
Triterpenoids
Oxidative stress
rotundic acid
Inflammation
Apoptosis
Cancer
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Summary:Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with a multitude of pharmacological activities. The primary emphasis of this study is on summarizing the anticancer properties with the underlying mechanisms of RA and its derivatives, as well as the pharmacokinetic features. Data was collected (up to date as of November 10, 2023) from various reliable and authentic literatures by searching in different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings imply that RA and its synthetic derivatives possess promising anti‐cancer properties against breast, colorectal, liver, and cervical cancers in various preclinical pharmacological test systems. The results also indicate that RA and its derivatives demonstrated anticancer effects via a number of cellular mechanisms, including apoptotic cell death, inhibition of oxidative stress, anti‐inflammatory effect, cytotoxicity, cell cycle arrest, anti‐proliferative effect, anti‐angiogenic effect, and inhibition of cancer cell migration and invasion. It has been proposed that RA and its derived compounds have the capability to serve as a hopeful chemotherapeutic agent, so further extensive clinical research is necessary.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202301492