Photodynamic Therapy Based on Nanoscale Metal–Organic Frameworks: From Material Design to Cancer Nanotherapeutics

Photodynamic therapy (PDT) is a highly effective, noninvasive, highly selective method for cancer treatment. Nanoscale metal–organic frameworks (NMOFs) are a type of crystalline hybrid material composed of metal centers and organic linkers. Owing to their adjustable structure, easy modification, per...

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Published inChemistry, an Asian journal Vol. 13; no. 21; pp. 3122 - 3149
Main Authors Guan, Qun, Li, Yan‐An, Li, Wen‐Yan, Dong, Yu‐Bin
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 02.11.2018
Subjects
Biocompatibility
Cancer
Chemistry
Metal-organic frameworks
Nanomaterials
nanotheranostics
Photodynamic therapy
nanotheranostics
cancer
nanomaterials
photodynamic therapy
metal-organic frameworks
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Summary:Photodynamic therapy (PDT) is a highly effective, noninvasive, highly selective method for cancer treatment. Nanoscale metal–organic frameworks (NMOFs) are a type of crystalline hybrid material composed of metal centers and organic linkers. Owing to their adjustable structure, easy modification, permanent pores, and good biocompatibility, NMOFs, as either nanophotosensitizers or photosensitizer nanocarriers, have been used in PDT. In this article, we summarize the recent progress in MOF‐based nanomaterials for tumor PDT. The MOF‐based nanomaterials might open up new avenues for the fabrication of new types of photosensitizers for PDT. Light delivery: Recent progress on metal–organic framework (MOF)‐based nanomaterials in tumor photodynamic therapy (PDT) is summarized, including design and fabrication strategies for MOF‐based PDT nanomaterials, and also the challenges faced in the use of MOF‐based PDT.
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ISSN:1861-4728
1861-471X
1861-471X
DOI:10.1002/asia.201801221