Dual-Functional Laser-Guided Magnetic Nanorobot Collectives against Gravity for On-Demand Thermo-Chemotherapy of Peritoneal Metastasis

• Published in: Advanced healthcare materials Vol. 13; no. 9; p. e2303361
• Main Authors: Wang, Longchen, Zou, Weijuan, Shen, Jian, Yang, Shihao, Wu, Jingjing, Ying, Tao, Cai, Xiaojun, Zhang, Li, Wu, Jianrong, Zheng, Yuanyi
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2024
• Subjects: peritoneum metastasis; magnetic nanorobot; drug delivery; photothermal therapy
• ISSN: 2192-2659
• DOI: 10.1002/adhm.202303361

Combining hyperthermic intraperitoneal chemotherapy with cytoreductive surgery is the main treatment modality for peritoneal metastatic (PM) carcinoma despite the off-target effects of chemotherapy drugs and the ineluctable side effects of total abdominal heating. Herein, a laser-integrated magnetic actuation system that actively delivers doxorubicin (DOX)-grafted magnetic nanorobot collectives to the tumor site in model mice for local hyperthermia and chemotherapy is reported. With intraluminal movements controlled by a torque-force hybrid magnetic field, these magnetic nanorobots gather at a fixed point coinciding with the position of the localization laser, moving upward against gravity over a long distance and targeting tumor sites under ultrasound imaging guidance. Because aggregation enhances the photothermal effect, controlled local DOX release is achieved under near-infrared laser irradiation. The targeted on-demand photothermal therapy of multiple PM carcinomas while minimizing off-target tissue damage is demonstrated. Additionally, a localization/treatment dual-functional laser-integrated magnetic actuation system is developed and validated in vivo, offering a potentially clinically feasible drug delivery strategy for targeting PM and other intraluminal tumors.