Curcumin‐based bioactive heterocycles derived via multicomponent reactions

• Published in: Archiv der Pharmazie (Weinheim) Vol. 356; no. 8; pp. e2300171 - n/a
• Main Authors: Nagargoje, Amol A., Shaikh, Mubarak H., Shingate, Bapurao B.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.08.2023
• Subjects: Biginelli reaction; curcumin‐based heterocycles; Hantzsch reaction; multicomponent reactions; pharmacological activities; multicomponent reactions; pharmacological activities; Biginelli reaction; Hantzsch reaction; curcumin-based heterocycles
• ISSN: 0365-6233; 1521-4184; 1521-4184
• DOI: 10.1002/ardp.202300171

Curcumin is an important phytochemical, found in the Asian countries, especially in the Indian subcontinent. The use of this “privileged natural product” in the diversity‐oriented synthesis of curcumin‐based heterocycles via multicomponent reactions (MCRs) is the subject of interest for many medicinal chemists across the globe. This review particularly focuses on the reactions involving curcuminoids as one of the reactants in the MCRs of curcuminoid to synthesize curcumin‐based heterocycles. Also, the various pharmacological activities of curcumin‐based heterocycles generated via the MCR approach are discussed. The research work published in the last 10 years is in the focus of this review article. The use of curcumin as one of the reactants in various multicomponent reactions (MCR) yielded diverse curcumin‐based heterocycles. This review focuses on recent advances in the synthetic strategies and medicinal attributes of these MCR‐derived curcumin‐based heterocycles, surveying research articles published in the last 10 years.