Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing

Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large‐area, homogeneous, and self‐standing porphyrin‐covalent organic framework (COF)‐based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polyme...

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Published inAdvanced healthcare materials Vol. 10; no. 8; pp. e2001821 - n/a
Main Authors Ding, Luo‐Gang, Wang, Song, Yao, Bing‐Jian, Li, Fei, Li, Yan‐An, Zhao, Guo‐Yan, Dong, Yu‐Bin
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.04.2021
Subjects
Anti-Bacterial Agents - pharmacology
Anti-Inflammatory Agents
Antiinfectives and antibacterials
Biocompatibility
Biomaterials
Biomedical materials
Chronic infection
Clinical medicine
COF band‐aids
drug delivery
Ibuprofen
In vivo methods and tests
Inflammation
Light effects
Membranes
Metal-Organic Frameworks
multifunctional porphyrin‐COF membranes
Pharmaceutical Preparations
photodynamic therapy
Porphyrins
Porphyrins - pharmacology
Singlet oxygen
Skin injuries
Wound Healing
wound healing
multifunctional porphyrin-COF membranes
COF band-aids
drug delivery
photodynamic therapy
Online AccessGet full text
ISSN2192-2640
2192-2659
2192-2659
DOI10.1002/adhm.202001821

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Abstract Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large‐area, homogeneous, and self‐standing porphyrin‐covalent organic framework (COF)‐based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph‐membrane exhibits highly effective antibacterial and anti‐inflammatory effects via synergistic light‐induced singlet oxygen (1O2) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph‐membrane‐based biocompatible “band‐aid” type dressing is fabricated, and its excellent anti‐infection and tissue remodeling activities are fully evidenced by in vivo chronic wound‐healing experiments. This study may inspire and promote the fabrication of many more new types of COF‐based multifunctional biomaterials for various skin injuries in clinical medicine. An ibuprofen‐loaded porphyrin‐COF‐based biocompatible and non‐toxic “band‐aid” type dressing is fabricated, and its excellent synergistic photodynamic antibacterial and controllable drug anti‐inflammatory effects are fully evidenced by in vitro and in vivo bacteria‐infected chronic wound‐healing experiments.
AbstractList Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large-area, homogeneous, and self-standing porphyrin-covalent organic framework (COF)-based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph-membrane exhibits highly effective antibacterial and anti-inflammatory effects via synergistic light-induced singlet oxygen (1 O2 ) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph-membrane-based biocompatible "band-aid" type dressing is fabricated, and its excellent anti-infection and tissue remodeling activities are fully evidenced by in vivo chronic wound-healing experiments. This study may inspire and promote the fabrication of many more new types of COF-based multifunctional biomaterials for various skin injuries in clinical medicine.Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large-area, homogeneous, and self-standing porphyrin-covalent organic framework (COF)-based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph-membrane exhibits highly effective antibacterial and anti-inflammatory effects via synergistic light-induced singlet oxygen (1 O2 ) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph-membrane-based biocompatible "band-aid" type dressing is fabricated, and its excellent anti-infection and tissue remodeling activities are fully evidenced by in vivo chronic wound-healing experiments. This study may inspire and promote the fabrication of many more new types of COF-based multifunctional biomaterials for various skin injuries in clinical medicine.
Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large‐area, homogeneous, and self‐standing porphyrin‐covalent organic framework (COF)‐based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph‐membrane exhibits highly effective antibacterial and anti‐inflammatory effects via synergistic light‐induced singlet oxygen (1O2) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph‐membrane‐based biocompatible “band‐aid” type dressing is fabricated, and its excellent anti‐infection and tissue remodeling activities are fully evidenced by in vivo chronic wound‐healing experiments. This study may inspire and promote the fabrication of many more new types of COF‐based multifunctional biomaterials for various skin injuries in clinical medicine.
Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large‐area, homogeneous, and self‐standing porphyrin‐covalent organic framework (COF)‐based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph‐membrane exhibits highly effective antibacterial and anti‐inflammatory effects via synergistic light‐induced singlet oxygen (1O2) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph‐membrane‐based biocompatible “band‐aid” type dressing is fabricated, and its excellent anti‐infection and tissue remodeling activities are fully evidenced by in vivo chronic wound‐healing experiments. This study may inspire and promote the fabrication of many more new types of COF‐based multifunctional biomaterials for various skin injuries in clinical medicine. An ibuprofen‐loaded porphyrin‐COF‐based biocompatible and non‐toxic “band‐aid” type dressing is fabricated, and its excellent synergistic photodynamic antibacterial and controllable drug anti‐inflammatory effects are fully evidenced by in vitro and in vivo bacteria‐infected chronic wound‐healing experiments.
Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large‐area, homogeneous, and self‐standing porphyrin‐covalent organic framework (COF)‐based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph‐membrane exhibits highly effective antibacterial and anti‐inflammatory effects via synergistic light‐induced singlet oxygen ( 1 O 2 ) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph‐membrane‐based biocompatible “band‐aid” type dressing is fabricated, and its excellent anti‐infection and tissue remodeling activities are fully evidenced by in vivo chronic wound‐healing experiments. This study may inspire and promote the fabrication of many more new types of COF‐based multifunctional biomaterials for various skin injuries in clinical medicine.
Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large-area, homogeneous, and self-standing porphyrin-covalent organic framework (COF)-based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph-membrane exhibits highly effective antibacterial and anti-inflammatory effects via synergistic light-induced singlet oxygen ( O ) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph-membrane-based biocompatible "band-aid" type dressing is fabricated, and its excellent anti-infection and tissue remodeling activities are fully evidenced by in vivo chronic wound-healing experiments. This study may inspire and promote the fabrication of many more new types of COF-based multifunctional biomaterials for various skin injuries in clinical medicine.
Author Zhao, Guo‐Yan
Ding, Luo‐Gang
Li, Yan‐An
Yao, Bing‐Jian
Wang, Song
Li, Fei
Dong, Yu‐Bin
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Keywords wound healing
multifunctional porphyrin-COF membranes
COF band-aids
drug delivery
photodynamic therapy
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Snippet Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large‐area, homogeneous,...
Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large-area, homogeneous,...
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SubjectTerms Anti-Bacterial Agents - pharmacology
Anti-Inflammatory Agents
Antiinfectives and antibacterials
Biocompatibility
Biomaterials
Biomedical materials
Chronic infection
Clinical medicine
COF band‐aids
drug delivery
Ibuprofen
In vivo methods and tests
Inflammation
Light effects
Membranes
Metal-Organic Frameworks
multifunctional porphyrin‐COF membranes
Pharmaceutical Preparations
photodynamic therapy
Porphyrins
Porphyrins - pharmacology
Singlet oxygen
Skin injuries
Wound Healing
Title Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadhm.202001821
https://www.ncbi.nlm.nih.gov/pubmed/33433952
https://www.proquest.com/docview/2515529275
https://www.proquest.com/docview/2477264027
Volume 10
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