Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing

• Published in: Advanced healthcare materials Vol. 10; no. 8; pp. e2001821 - n/a
• Main Authors: Ding, Luo‐Gang, Wang, Song, Yao, Bing‐Jian, Li, Fei, Li, Yan‐An, Zhao, Guo‐Yan, Dong, Yu‐Bin
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.04.2021
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Inflammatory Agents; Antiinfectives and antibacterials; Biocompatibility; Biomaterials; Biomedical materials; Chronic infection; Clinical medicine; COF band‐aids; drug delivery; Ibuprofen; In vivo methods and tests; Inflammation; Light effects; Membranes; Metal-Organic Frameworks; multifunctional porphyrin‐COF membranes; Pharmaceutical Preparations; photodynamic therapy; Porphyrins; Porphyrins - pharmacology; Singlet oxygen; Skin injuries; Wound Healing; wound healing; multifunctional porphyrin-COF membranes; COF band-aids; drug delivery; photodynamic therapy
• ISSN: 2192-2640; 2192-2659; 2192-2659
• DOI: 10.1002/adhm.202001821

Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large‐area, homogeneous, and self‐standing porphyrin‐covalent organic framework (COF)‐based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph‐membrane exhibits highly effective antibacterial and anti‐inflammatory effects via synergistic light‐induced singlet oxygen (1O2) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph‐membrane‐based biocompatible “band‐aid” type dressing is fabricated, and its excellent anti‐infection and tissue remodeling activities are fully evidenced by in vivo chronic wound‐healing experiments. This study may inspire and promote the fabrication of many more new types of COF‐based multifunctional biomaterials for various skin injuries in clinical medicine. An ibuprofen‐loaded porphyrin‐COF‐based biocompatible and non‐toxic “band‐aid” type dressing is fabricated, and its excellent synergistic photodynamic antibacterial and controllable drug anti‐inflammatory effects are fully evidenced by in vitro and in vivo bacteria‐infected chronic wound‐healing experiments.