Active Metabolites from Endolichenic Fungus Talaromyces sp

• Published in: Chemistry & biodiversity Vol. 15; no. 11; pp. e1800371 - n/a
• Main Authors: Yuan, Wei‐Hua, Teng, Meng‐Ting, Sun, Shan‐Shan, Ma, Lin, Yuan, Bo, Ren, Qiang, Zhang, Peng
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.11.2018
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - metabolism; Antineoplastic Agents, Phytogenic - pharmacology; antioxidant activity; Antioxidants; Antioxidants - chemistry; Antioxidants - metabolism; Antioxidants - pharmacology; biological activity; Biphenyl Compounds - antagonists & inhibitors; Cell Line, Tumor; Cell Survival - drug effects; cytotoxicity; Data interpretation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; endolichenic fungus; Ergosterol; Free Radicals - antagonists & inhibitors; Fungi; Humans; Lactones - metabolism; Lactones - pharmacology; Metabolites; Molecular Structure; Palmitic acid; Parmeliaceae - chemistry; Parmeliaceae - metabolism; Picrates - antagonists & inhibitors; Structure-Activity Relationship; Talaromyces; Talaromyces - chemistry; Talaromyces - metabolism; talaromycin A; X ray spectra; X-ray diffraction; talaromycin A; biological activity; endolichenic fungus; antioxidant activity; metabolites; Talaromyces; cytotoxicity
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.201800371

The active metabolites investigation of Talaromyces sp. (strain No. MH551540) associated with Xanthoparmelia angustiphylla afforded one new δ‐lactone, talaromycin A (1), together with six known compounds, clearanol A (2), 6‐methylbiphenyl‐3,3′,4,5′‐tetraol (3), desmethylaltenusin (4), ergone (5), ergosterol (6), and palmitic acid (7). The structures of these compounds were elucidated by a combination of spectroscopic‐data interpretation and single‐crystal X‐ray diffraction analysis. The cytotoxicities of 1–7 and the antioxidant activities of 3 and 4 were also evaluated.