An Iridium Complex as an AIE‐active Photosensitizer for Image‐guided Photodynamic Therapy
Image‐guided photodynamic therapy (PDT) has received growing attention due to its non‐invasiveness and precise controllability. However, the PDT efficiency of most photosensitizers are decreased in living system due to the aggregation‐caused singlet oxygen (1O2) generation decreasing. Herein, we pre...
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Published in | Chemistry, an Asian journal Vol. 16; no. 13; pp. 1780 - 1785 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Wiley Subscription Services, Inc
05.07.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Image‐guided photodynamic therapy (PDT) has received growing attention due to its non‐invasiveness and precise controllability. However, the PDT efficiency of most photosensitizers are decreased in living system due to the aggregation‐caused singlet oxygen (1O2) generation decreasing. Herein, we present an Iridium (III) pyridylpyrrole complex (Ir‐1) featuring of aggregation‐induced emission (AIE) and 1O2 generation characteristics for image‐guided PDT of cancer. Ir‐1 aqueous solution exhibits bright red phosphorescence peaked at 630 nm, large Stokes shift of 227 nm, and good 1O2 generation ability. The 1O2 generating rate of Ir‐1 in EtOH/water mixture solution is 2.3 times higher than that of Rose Bengal. In vitro experimental results revealed that Ir‐1 has better biocompatibility and higher phototoxicity compared with clinically used photosensitizers (Rose Bengal and Ce6), suggesting that Ir‐1 can serve as a photosensitizer for image‐guided PDT of cancer.
An Iridium (III) complex (Ir‐1) featuring aggregation‐induced emission and 1O2 generation characteristics were prepared. Ir‐1 has better biocompatibility and higher phototoxicity compared with clinically used photosensitizers. The application of Ir‐1 in imaging‐guided photodynamic therapy was demonstrated. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1861-4728 1861-471X |
DOI: | 10.1002/asia.202100291 |