Terpenes from Euphorbia antiquorum and Their in Vitro Anti‐HIV Activity

Three new compounds (1 – 3), including two euphane type triterpenes, 24,24‐dimethoxy‐25,26,27‐trinoreuphan‐3β‐ol (1) and (24S)‐24‐hydroperoxyeupha‐8,25‐dien‐3β‐ol (2), and an ent‐atisine diterpene, ent‐atisane‐3α,16α,17‐triol (3), were isolated from an acetone extract of the stems of Euphorbia antiq...

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Published inChemistry & biodiversity Vol. 15; no. 5; pp. e1700560 - n/a
Main Authors Dong, Miao, Chen, Xuan‐Qin, Chen, Chin‐Ho, Li, Rong‐Tao
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.05.2018
Subjects
Acetone
anti‐HIV
Diterpenes
Euphorbia
Euphorbia antiquorum
HIV
Human immunodeficiency virus
NMR
Nuclear magnetic resonance
Terpenes
Triterpenes
diterpenes
anti-HIV
Euphorbia antiquorum
triterpenes
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Summary:Three new compounds (1 – 3), including two euphane type triterpenes, 24,24‐dimethoxy‐25,26,27‐trinoreuphan‐3β‐ol (1) and (24S)‐24‐hydroperoxyeupha‐8,25‐dien‐3β‐ol (2), and an ent‐atisine diterpene, ent‐atisane‐3α,16α,17‐triol (3), were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4 – 11). The structures of compounds (1 – 11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV‐1 replication in vitro (EC50 = 1.38 μm).
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ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.201700560