The effect of vitamin D supplementation in combination with low-calorie diet on anthropometric indices and androgen hormones in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial

• Published in: Journal of endocrinological investigation Vol. 41; no. 5; pp. 597 - 607
• Main Authors: Jafari-Sfidvajani, S., Ahangari, R., Hozoori, M., Mozaffari-Khosravi, H., Fallahzadeh, H., Nadjarzadeh, A.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2018; Springer Nature B.V
• Subjects: 25-Hydroxyvitamin D; Androgens; Body composition; Body fat; Body mass index; Body weight; Body weight loss; Clinical Number; Clinical trials; Dehydroepiandrosterone; Dehydroepiandrosterone sulfate; Dietary supplements; Double-blind studies; Endocrinology; Globulins; Hip; Hormones; Hypocaloric diet; IRCT2016062710826N19; Medicine; Medicine & Public Health; Menstrual cycle; Menstruation; Metabolic Diseases; Nutrient deficiency; Original Article; Overweight; Polycystic ovary syndrome; Sulfates; Testosterone; Vitamin D; Vitamin D3; Polycystic ovary syndrome; Androgens; Vitamin D; Low-calorie diet; Menstrual cycle; Randomized controlled trial
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-017-0785-9

Purpose Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in reproductive age women. The aim of this studywas to evaluate the effects of vitamin D supplementation in combination with low-calorie diet on anthropometric indices, reproductive hormones and menstrual regularity in overweight and obese PCOS women. Methods In this randomized controlled clinical trial, 60 PCOS women with vitamin D insufficiency were randomly assigned to 12 weeks of either (1) weight-loss intervention + 50,000 IU/week oral vitamin D3 or (2) weight-loss intervention + placebo. At the beginning and end of the study, the anthropometric indices, body composition, 25-hydroxyvitamin D, total testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG) and free androgen index (FAI) were measured and regularity of menses was compared among the two groups. Result After 12-week intervention, median of serum 25-hydroxyvitamin D3 significantly increased from 18.5 (10.75–20) ng/ml to 42.69 (34–53.25) ng/ml in vitamin D group compared to placebo group ( p  < 001). Moreover, there was a significant improvement in frequency regular menstrual cycle ( p  = 0.01). Mean of weight, body mass index, fat mass, waist and hip circumference and waist-to-hip ratio significantly decreased in both groups, but was not different between two groups. Mean of total testosterone insignificantly decreased from 0.7 to 0.5 ng/ml in vitamin D group ( p  = 0.18). In addition, we did not observe significant differences regarding DHEAS, FAI and SHBG between two groups. Conclusions In women with PCOS, androgen profile did not change with vitamin D supplementation when combined with low-calorie diet, but menstrual frequency significantly improved. Clinical Trial Registration Number IRCT2016062710826N19.