Gamma-synuclein binds synaptic vesicles but does not interact with SNARE-complex proteins

The purpose of this study was to determine whether gamma synuclein binds to synaptic vesicles as well as to compare the mechanisms of interaction of alpha and gamma synucleins with synaptic vesicles. The results of this study indicate that gamma synu clein is capable of binding to synaptic vesicles,...

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Published inDoklady. Biochemistry and biophysics Vol. 456; no. 1; pp. 108 - 110
Main Authors Lytkina, O. A., Tarasova, T. V., Khritankova, I. V., Anokhin, P. K., Kukharsky, M. S., Ustyugov, A. A., Bachurin, S. O.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.05.2014
Springer Nature B.V
Subjects
alpha-Synuclein - genetics
alpha-Synuclein - metabolism
Animals
beta-Synuclein - genetics
beta-Synuclein - metabolism
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Corpus Striatum - metabolism
gamma-Synuclein - genetics
gamma-Synuclein - metabolism
Immunoblotting
Life Sciences
Mice, Knockout
Molecular biology
Proteins
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
SNARE Proteins - metabolism
Synaptic Vesicles - metabolism
Synaptic Vesicle
Alpha Synuclein
DOKLADY Biochemistry
Triple Knockout
Potassium Tartrate
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Summary:The purpose of this study was to determine whether gamma synuclein binds to synaptic vesicles as well as to compare the mechanisms of interaction of alpha and gamma synucleins with synaptic vesicles. The results of this study indicate that gamma synu clein is capable of binding to synaptic vesicles, but the mechanism of its interaction with these structures is fundamentally different from the mechanism proposed for alpha synuclein.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672914030089