Palladium-catalyzed asymmetric allylic alkylation of indoles by C–N bond axially chiral phosphine ligands

The palladium-catalyzed asymmetric allylic alkylation of indoles with 1,3-diphenyl-2-propenyl acetate using P/N-type ligands such as N-aryl indole, C–N bond axially chiral aminophosphine (aS)-L4, gave the desired products 1 in good yields and with moderate to high enantioselectivities (up to 90% ee)...

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 24; no. 8; pp. 499 - 504
Main Authors Mino, Takashi, Ishikawa, Miho, Nishikawa, Kenji, Wakui, Kazuya, Sakamoto, Masami
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 30.04.2013
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
HYDRAZONES
SUBSTITUTION
PD
RESOLUTION
CHEMISTRY
PYRROLES
ALKALOIDS
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Summary:The palladium-catalyzed asymmetric allylic alkylation of indoles with 1,3-diphenyl-2-propenyl acetate using P/N-type ligands such as N-aryl indole, C–N bond axially chiral aminophosphine (aS)-L4, gave the desired products 1 in good yields and with moderate to high enantioselectivities (up to 90% ee).
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2013.03.008