Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case–control studies of incidence and associated risk factors

• Published in: European journal of clinical pharmacology Vol. 74; no. 4; pp. 405 - 411
• Main Authors: Mori, Nobuaki, Kamimura, Yoshio, Kimura, Yuki, Hirose, Shoko, Aoki, Yasuko, Bito, Seiji
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2018; Springer Nature B.V
• Subjects: Acidosis; Antibiotics; Biomedical and Life Sciences; Biomedicine; Clinical Trial; Comparative analysis; Incidence; Lactic acid; Lactic acidosis; Linezolid; Pharmacology/Toxicology; Renal insufficiency; Risk factors; Vancomycin; Propensity score-matched analysis; Linezolid-associated lactic acidosis; Renal insufficiency; Vancomycin-associated lactic acidosis
• ISSN: 0031-6970; 1432-1041
• DOI: 10.1007/s00228-017-2377-1

Purpose Lactic acidosis is a rare complication of linezolid (LZD) therapy, and its incidence and risk factors remain unknown. This study aimed to compare the incidence of LZD-associated lactic acidosis (LALA) and vancomycin (VAN)-associated lactic acidosis (VALA) and investigate the risk factors for LALA. Methods We performed a retrospective cohort study using propensity score-matched analyses comparing the incidence of lactic acidosis between LZD and VAN therapy. We included adult patients administered LZD or VAN between April 2014 and March 2016 and extracted patient baseline data. In a case–control study, we identified the risk factors of lactic acidosis in patients treated with LZD. Results We identified 94 and 313 patients who were administered LZD and VAN, respectively. The incidence of lactic acidosis after LZD and VAN therapy was 10.6 and 0.3%, respectively. After propensity score-matched analyses, the incidence of lactic acidosis with LZD therapy was significantly higher than that with VAN therapy [10.0% (8/80) vs. 0% (0/80), respectively; risk difference, 0.1; 95% confidence interval (CI), 0.03–0.17; p  = 0.004]. In a case–control study, 10 patients with LALA were matched to 20 non-lactic acidosis patients by age and sex. Patients with LALA were more likely to have renal insufficiency than non-lactic acidosis patients that were in the univariate analysis (odds ratio, 7.4; 95% CI, 1.0–84.4; p  = 0.02). Conclusions This study indicates that LALA occurs more frequently than VALA does and is associated with renal insufficiency. Therefore, close monitoring of kidney function and serum lactate is recommended during LZD therapy.