Fluorescent x-ray computed tomography using the pinhole effect for biomedical applications

We propose a fluorescent x-ray computed tomography using volumetric beam and pinhole collimator to obtain 3-dimensional image effectively, aimed at providing molecular imaging with quantifiable measures and sub-millimeter spatial resolution. In this study, we demonstrate the feasibility of this conc...

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Bibliographic Details
Published inOptics communications Vol. 297; pp. 210 - 214
Main Authors Sunaguchi, Naoki, Yuasa, Tetsuya, Hyodo, Kazuyuki, Zeniya, Tsutomu
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.06.2013
Subjects
Computed tomography
Fluorescent x-ray
Molecular imaging
Synchrotron radiation
Molecular imaging
Computed tomography
Fluorescent x-ray
Synchrotron radiation
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Summary:We propose a fluorescent x-ray computed tomography using volumetric beam and pinhole collimator to obtain 3-dimensional image effectively, aimed at providing molecular imaging with quantifiable measures and sub-millimeter spatial resolution. In this study, we demonstrate the feasibility of this concept and investigate imaging properties such as spatial resolution, contrast resolution and quantifiable measures, by imaging physical phantoms. A preliminary imaging system using monochromatic synchrotron x-rays was constructed at the BLNE-7A bending-magnet beamline (6.5GeV) at KEK, Japan.
ISSN:0030-4018
1873-0310
DOI:10.1016/j.optcom.2013.01.071