Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma

• Published in: Breast cancer research and treatment Vol. 87; no. 2; pp. 197 - 201
• Main Authors: SENSI, Elisa, TANCREDI, Mariella, ARETINI, Paolo, CIPOLLINI, Giovanna, COLLECCHI, Paola, NACCARATO, A. Giuseppe, VIACAVA, Paolo, BEVILACQUA, Generoso, CALIGO, Maria A
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.09.2004; Springer Nature B.V
• Subjects: Biological and medical sciences; Breast cancer; Breast Neoplasms - genetics; Cancer research; Cancer therapies; Carcinoma - genetics; DNA Damage; DNA Mutational Analysis; Female; GADD45 Proteins; Genes; Genetic Predisposition to Disease; Gynecology. Andrology. Obstetrics; Heredity; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Loss of Heterozygosity; Mammary gland diseases; Medical research; Medical sciences; Mutation; Pedigree; Proteins - genetics; Tumors; Human; Mammary gland diseases; Breast carcinoma; GADD45 gene; Gene; hereditary breast cancer; Genetics; Breast cancer; Malignant tumor; Hereditary
• ISSN: 0167-6806; 1573-7217
• DOI: 10.1023/B:BREA.0000041625.60280.4a

GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.