Biomimetic fabrication and biocompatibility of hydroxyapatite/chitosan nanohybrid coatings on porous carbon fiber felts

• Published in: Materials letters Vol. 128; pp. 31 - 34
• Main Authors: Liu, Yu-Tai, Long, Teng, Tang, Sha, Sun, Jin-Liang, Zhu, Zhen-An, Guo, Ya-Ping
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2014
• Subjects: Bioceramics; Biomaterials; Carbon materials; Nanocomposites; Porous materials; Bioceramics; Nanocomposites; Carbon materials; Porous materials; Biomaterials
• ISSN: 0167-577X; 1873-4979
• DOI: 10.1016/j.matlet.2014.04.117

Hydroxyapatite (HA)/chitosan nanohybrid coatings (HA/CS/CFs) on porous carbon fiber felts (PCFFs) have been fabricated according to the following stages: (i) deposition of chitosan/calcium phasphate precursors on PCFFs by dip-coating method and (ii) in situ formation of HA/CS/CFs by biomimetic method. PCFFs are covered uniformly with HA nanorods and chitosan, and the macropores in PCFFs still remained. Interestingly, the calcium-deficient HA nanorods with a diameter of ~20nm and length of 50–100nm possess poor crystallinity. HA/CS/CFs exhibit the excellent in vitro biocompatibility, which can improve adhesion, spreading, and proliferation of human bone marrow stromal cells (hBMSCs). Hence, HA/CS/CFs have great potential for bone scaffold materials. [Display omitted] •Hydroxyapatite/chitosan nanohybrid coatings deposit on porous carbon fiber felts.•Calcium-deficient apatite nanorods are dispersed among chitosan.•Hydroxyapatite/chitosan nanohydrid coatings are formed via biomineralization process.•The nanohydrid coatings exhibit excellent biocompatibility.