The prognostic value of elevated ezrin in patients with osteosarcoma

• Published in: Tumor biology Vol. 35; no. 2; pp. 1263 - 1266
• Main Authors: Lun, Deng-Xing, Hu, Yong-Cheng, Xu, Zhao-Wan, Xu, Li-Na, Wang, Bin-Wu
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2014; Springer Nature B.V
• Subjects: Biomarkers; Biomarkers, Tumor - genetics; Biomedical and Life Sciences; Biomedicine; Bone cancer; Bone Neoplasms - genetics; Bone Neoplasms - mortality; Bone Neoplasms - pathology; Cancer Research; Cytoskeletal Proteins - biosynthesis; Cytoskeletal Proteins - genetics; Disease-Free Survival; Gene expression; Gene Expression Regulation, Neoplastic; Humans; Medical prognosis; Meta-analysis; Osteosarcoma - genetics; Osteosarcoma - mortality; Osteosarcoma - pathology; Prognosis; Research Article; Prognosis; Osteosarcoma; Ezrin; Disease-free survival; Meta-analysis
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-013-1168-2

Published studies researching the prognostic significance of ezrin expression in patients with osteosarcoma are inconclusive and heterogeneous. We conducted a meta-analysis to assess its prognostic value more precisely. The hazard ratios with corresponding 95 % confidence intervals were calculated to evaluate the effects. Five studies with 318 osteosarcoma patients were included to estimate the relationship between ezrin and disease-free survival, and ezrin and overall survival. Compared with osteosarcoma patients with low or negative ezrin expression, patients with high ezrin expression tended to be associated with lower disease-free survival, but the difference was not significant. However, patients with high ezrin expression were obviously associated with lower overall survival. Therefore, the findings from this systematic review suggest that ezrin expression is an effective biomarker of prognosis in patients with osteosarcoma.