Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study

• Published in: Journal of endocrinological investigation Vol. 39; no. 9; pp. 1045 - 1053
• Main Authors: Popa, S., Moţa, M., Popa, A., Moţa, E., Serafinceanu, C., Guja, C., Catrinoiu, D., Hâncu, N., Lichiardopol, R., Bala, C., Roman, G., Radulian, G., Timar, R., Mihai, B.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2016; Springer Nature B.V
• Subjects: Abdomen; Adult; Aged; Body weight; Cardiovascular Diseases - complications; Cardiovascular Diseases - epidemiology; Case-Control Studies; Cross-Sectional Studies; Diabetes mellitus; Dietary fiber; Endocrinology; Female; Genotype & phenotype; High density lipoprotein; Humans; Hypertriglyceridemia; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - epidemiology; Middle Aged; Obesity; Obesity - complications; Obesity - epidemiology; Obesity, Abdominal - complications; Obesity, Abdominal - epidemiology; Original Article; Overweight; Overweight - complications; Overweight - epidemiology; Phenotype; Population studies; Population-based studies; Prevalence; Prognosis; Risk Factors; Romania - epidemiology; Young Adult; Metabolically healthy overweight/obesity phenotype; Metabolically unhealthy lean phenotype; Romania; Obesity/overweight; Metabolic syndrome; PREDATORR study
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-016-0470-4

Purpose The objectives were to assess the prevalence of overweight/obesity, abdominal obesity and metabolic syndrome (MetS), and to evaluate the characteristics of the metabolically unhealthy lean (MUHL) and metabolically healthy overweight/obese (MHO) phenotypes in a Romanian population-based sample from the PREDATORR study. Methods PREDATORR was an epidemiological study with a stratified, cross-sectional, cluster random sampling design. Participants were classified into four cardiometabolic phenotypes based on the BMI, the cut-off value being 25 kg/m 2 , and the presence of MetS (defined according to the Harmonization definition 2009): MUHL, MHO, metabolically healthy lean (MHL) and metabolically unhealthy overweight/obese (MUHO). Results Overall, 2681 subjects aged 20–79 years were included in the analysis. The overall age and sex-adjusted prevalence of obesity was 31.90 %, overweight was 34.7 %, abdominal obesity was 73.90 % and MetS was 38.50 %. The age- and sex-adjusted prevalence of MHO phenotype was 31.60 %, while MUHL phenotype prevalence was 3.90 %. MUHL and MHO participants had a cardiometabolic profile, kidney function and CVD risk intermediary between MHL and MUHO. MUHL had higher odds of being associated with CVD risk (OR 5.8; p  < 0.001), abdominal obesity, prediabetes, diabetes, hypertriglyceridemia and hypo-HDL cholesterolemia than MHL, while MHO phenotype was associated with hypo-HDL cholesterolemia (OR 3.1; p  = 0.002), prediabetes (OR 2.9; p  < 0.001) and abdominal obesity. Conclusions PREDATORR study showed a high prevalence of obesity/overweight, abdominal obesity and MetS in the adult Romanian population, and their association with kidney function and several cardiometabolic factors.