More than an Anti-diabetic Bariatric Surgery, Metabolic Surgery Alleviates Systemic and Local Inflammation in Obesity

Obesity, associated with increased risk of type 2 diabetes (T2D), cardiovascular disease, and hepatic steatosis et al., has become a major global health problem. Recently, obesity has been proven to be under a status of low-grade, chronic inflammation, which contributes to insulin resistance and T2D...

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Published inObesity surgery Vol. 28; no. 11; pp. 3658 - 3668
Main Authors Zhang, Chunlan, Zhang, Jingjing, Liu, Zhenqi, Zhou, Zhiguang
Format Journal Article
LanguageEnglish
Published New York Springer US 01.11.2018
Springer Nature B.V
Subjects
Antidiabetics
Fatty liver
Fish oils
Gastrointestinal surgery
Inflammation
Medicine
Medicine & Public Health
Obesity
Review Article
Surgery
Type 2 diabetes
Obesity
Inflammation
Bariatric surgery
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Summary:Obesity, associated with increased risk of type 2 diabetes (T2D), cardiovascular disease, and hepatic steatosis et al., has become a major global health problem. Recently, obesity has been proven to be under a status of low-grade, chronic inflammation, which contributes to insulin resistance and T2D. Bariatric surgery is currently an effective treatment for the control of morbid obesity and T2D, which impels ongoing efforts to clarify physiological and molecular mechanisms mediating these benefits. The correlation between obesity, inflammation, and T2D has been revealed to a certain extent, and studies have shed light on the effect of bariatric surgery on inflammatory status of subjects with obesity. Based on recent findings, this review focuses on the relationship between inflammation, obesity, and bariatric surgery.
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ISSN:0960-8923
1708-0428
1708-0428
DOI:10.1007/s11695-018-3400-z