Recombinant 1F9 spidroin microgels for murine full-thickness wound repairing

• Published in: Doklady. Biochemistry and biophysics Vol. 466; no. 1; pp. 9 - 12
• Main Authors: Moisenovich, M. M., Malyuchenko, N. V., Arkhipova, A. Yu, Goncharenko, A. V., Kotlyarova, M. S., Davydova, L. I., Vasil’eva, T. V., Bogush, V. G., Agapov, I. I., Debabov, V. G., Kirpichnikov, M. P.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2016; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Biophysics and Molecular Biology; Female; Fibroins - genetics; Fibroins - pharmacology; Genetic recombination; Hydrogels - chemistry; Hydrogels - pharmacology; Infections; Life Sciences; Mice; Mice, Inbred C57BL; Recombinant Proteins - genetics; Recombinant Proteins - pharmacology; Skin; Wound healing; Wound Healing - drug effects; DOKLADY Biochemistry; Skin Appendage; Full Thickness Wound; Wind Edge; Hair Follicle
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S1607672916010038

The study of the stimulating effect of the microgels (MGs) based on recombinant 1F9 spidroin on the regeneration of the deep skin wound in mice was carried out. The use of spidroin MGs was shown to increase significantly the quality of healing compared to the control. The introduction of the MG in the wound edges led to recovery of all the structural elements of the skin: the epidermis, the dermis, including vascular and nervous network, in the periphery of the wound underlying muscles, and skin appendages (sebaceous and sweat glands and hair follicles) was revealed.