Bovine Anaplasmosis: Will there ever be an almighty effective vaccine?

Bovine anaplasmosis is a tick-borne bacterial disease with a worldwide distribution and the cause of severe economic losses in the livestock industry in many countries, including México. In the present work, we first review the elements of the immune response of the bovine, which allows ameliorating...

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Published inFrontiers in veterinary science Vol. 9; p. 946545
Main Authors Salinas-Estrella, Elizabeth, Amaro-Estrada, Itzel, Cobaxin-Cárdenas, Mayra E., Preciado de la Torre, Jesús F., Rodríguez, Sergio D.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 05.10.2022
Subjects
Anaplasma marginale
bovine anaplasmosis
immunity
inactivated vaccine
live vaccines
Veterinary Science
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Summary:Bovine anaplasmosis is a tick-borne bacterial disease with a worldwide distribution and the cause of severe economic losses in the livestock industry in many countries, including México. In the present work, we first review the elements of the immune response of the bovine, which allows ameliorating the clinical signs while eliminating the majority of the blood forms and generating an immunologic memory such that future confrontations with the pathogen will not end in disease. On the other hand, many vaccine candidates have been evaluated for the control of bovine anaplasmosis yet without no commercial worldwide effective vaccine. Lastly, the diversity of the pathogen and how this diversity has impaired the many efforts to control the disease are reviewed.
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This article was submitted to Veterinary Infectious Diseases, a section of the journal Frontiers in Veterinary Science
Reviewed by: Alejandro Cabezas-Cruz, Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), France; Katja Mertens-Scholz, Friedrich-Loeffler-Institute, Germany; Hans-Joachim Schuberth, University of Veterinary Medicine Hannover, Germany
Edited by: Hua-Ji Qiu, Harbin Veterinary Research Institute (CAAS), China
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2022.946545