Adverse Effects Profile of Dicycloplatin (DCP) Offers Chemotherapeutic Advantage Over Cisplatin and Carboplatin

• Published in: Anticancer research Vol. 39; no. 8; pp. 4455 - 4462
• Main Authors: YU, JING JIE, HOGAN, THOMAS, MORLEY, CHAD, CRIGGER, CHAD, JIAO, SHUNCHANG, WILLIAMS, DORIAN J., SALKINI, MOHAMAD W., YANG, XUQING, LIANG, XIAOBING, YAN, BINGXUE, CECIL, COURTNEY, WINN, AVA C., ZHENG, JENNY, GUO, YI, JIANG, BING-HUA, WASHINGTON, IDA M.
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.08.2019
• Subjects: Animals; Antibodies; Apoptosis; Biocompatibility; Bone marrow; Bone Marrow - drug effects; Bone Marrow - pathology; Cancer; Cancer therapies; Carboplatin; Carboplatin - administration & dosage; Carboplatin - adverse effects; Cells; Chemotherapy; Cisplatin; Cisplatin - administration & dosage; Cisplatin - adverse effects; Clinical trials; Cystoscopy; Disease Models, Animal; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Drugs; FDA approval; Female; Flow cytometry; Glutamates - administration & dosage; Glutamates - adverse effects; Humans; Immune status; Immunoblotting; In vivo methods and tests; Laboratory animals; Medical research; Mice; Molecular weight; Myelosuppression; Neoplasms - drug therapy; Neurotoxicity; Organoplatinum Compounds - administration & dosage; Organoplatinum Compounds - adverse effects; Ovaries; Proteins; Remission; Side effects; Spleen; Spleen - drug effects; Spleen - pathology; Surveillance; Testicular cancer; Beijing China; St Louis Missouri; United States > US; China; therapeutic advance; Chemotherapy; dicycloplatin (DCP); tolerable side effects
• ISSN: 0250-7005; 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.13618

Platinum-based chemotherapy often fails due to its severe adverse effects. The aim of this study was to examine the adverse effects profile and efficacy of dicycloplatin and compare them to those of cisplatin and carboplatin. Cystoscopy surveillance of the first American cancer patient treated with dicycloplatin was performed quarterly. In vitro and in vivo studies were conducted using immunoblotting and flow cytometry to assess immune status of spleen and bone marrow of mice treated with dicycloplatin, cisplatin and carboplatin. The American patient did not suffer clinically significant myelosuppression; dicycloplatin has sustained remission in this patient to date. Experimental studies showed that dicycloplatin is less toxic to bone marrow and spleen of mice than cisplatin and carboplatin. Dicycloplatin is a promising drug in cancer chemotherapy with less aggressive side-effects than those typically associated with cisplatin and carboplatin. This is an important therapeutic advantage in cancer chemotherapy. Clinical investigation of dicycloplatin as an alternative to cisplatin or carboplatin is warranted.