Conducting moisture sensitive reactions under mechanochemical conditions

Dry organic solvents are used for various organic reactions that employ moisture sensitive reagents. The processes to dry these solvents are hazardous and costly. Setting up reactions in an open atmosphere while using moisture sensitive reagents has little to no effect on the rate or yield of the re...

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Bibliographic Details
Published inTetrahedron letters Vol. 53; no. 34; pp. 4510 - 4513
Main Authors Waddell, Daniel C., Clark, Tammara D., Mack, James
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 22.08.2012
Subjects
Ball milling
Green chemistry
Mechanochemistry
Solid state
Solvent-free synthesis
Ball milling
Solid state
Green chemistry
Solvent-free synthesis
Mechanochemistry
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Summary:Dry organic solvents are used for various organic reactions that employ moisture sensitive reagents. The processes to dry these solvents are hazardous and costly. Setting up reactions in an open atmosphere while using moisture sensitive reagents has little to no effect on the rate or yield of the reaction under solvent-free mechanochemical conditions. We believe this is partly due to the gaseous nature of the water vapor in the air compared to the dissolved water and oxygen in solution. Dry organic solvents are used for various organic reactions that employ moisture sensitive reagents. The processes to dry these solvents are hazardous and costly. Setting up reactions in an open atmosphere while using moisture sensitive reagents has little to no effect on the rate or yield of the reaction under mechanochemical conditions. We believe this is partly due to the gaseous nature of the water vapor in the air compared to the dissolved water and oxygen in solution.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.06.009