Association of PTX3 Genetic Variants With Development of Diabetic Neuropathy

• Published in: In vivo (Athens) Vol. 39; no. 2; pp. 702 - 712
• Main Authors: HSU, YUNG-NAN, FAN, YING-CHI, SU, SHIH-CHI, CHANG, LUN-CHING, YANG, SHUN-FA
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.03.2025
• Subjects: Adult; Aged; Alleles; C-Reactive Protein - genetics; Case-Control Studies; Cholesterol; Diabetes; Diabetic Neuropathies - diagnosis; Diabetic Neuropathies - genetics; Diabetic Neuropathies - pathology; Diabetic neuropathy; Disease; Female; Gene Frequency; Genes; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Inflammation; Low density lipoprotein; Male; Metabolism; MicroRNAs; Middle Aged; Pathogenesis; Polymorphism, Single Nucleotide; Proteins; Serum Amyloid P-Component - genetics; United States > US; cholesterol; gene polymorphism; Pentraxin 3; diabetic neuropathy
• ISSN: 0258-851X; 1791-7549; 1791-7549
• DOI: 10.21873/invivo.13874

Pentraxin 3 (PTX3), initially discovered as a key player in the defense against infectious pathogens, is crucial for inflammation and tissue regeneration. This study aimed to explore the impact of gene variants on the development and progression of diabetic neuropathy (DN). The potential impact of gene variants on the susceptibility to DN was examined by genotyping four single-nucleotide polymorphisms (SNPs) of the gene (rs1840680, rs2305619, rs3816527, and rs2120243) in a study involving 730 DN cases and 861 diabetic controls with normal neurologic function. We demonstrated that diabetic subjects homozygous for the minor allele at rs1840680 [AA; adjusted odds ratio (AOR)=1.486; 95% confidence interval (CI)=1.050-2.103; =0.02] or rs2120243 (AA; AOR=1.483; 95%CI=1.051-2.091; =0.025) were more likely to develop neurologic complications compared to those homozygous for the corresponding major allele. Further stratification revealed that this correlation with DN risk was observed specifically in males but not in females. In addition, another SNP of the gene, rs2305619, was found to be associated with the risk for DN in males (AA GG, AOR=1.686; 95%CI=1.086-2.617, =0.020), indicating a sex-specific impact of gene polymorphisms on damage to the nerves in diabetic patients. Furthermore, DN patients homozygous for the minor allele of rs1840680 (AA), particularly males, had higher levels of LDL-cholesterol than those homozygous for the reference allele (GG) ( =0.034). gene polymorphisms are associated with dyslipidemia and nerve damage in diabetic patients in a sex-specific manner.