Aggregation behavior of short-chained archaeal phospholipid analogs: Contribution of methyl branches to lipid hydrophobicity and membrane formability
The aggregation behavior of short-chained archaeal phospholipid analogs (DCn+mPCs, (n, m) = (4, 1) and (8, 2), n: number of carbon atoms in the single main chain; m: number of methyl branches in one chain. PC denotes phosphatidylcholine) in water was investigated as a function of the hydrophobic cha...
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Published in | Colloid and interface science communications Vol. 32; p. 100200 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
01.09.2019
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Subjects | |
Online Access | Get full text |
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Summary: | The aggregation behavior of short-chained archaeal phospholipid analogs (DCn+mPCs, (n, m) = (4, 1) and (8, 2), n: number of carbon atoms in the single main chain; m: number of methyl branches in one chain. PC denotes phosphatidylcholine) in water was investigated as a function of the hydrophobic chain length and the glycerol-linkage type (ester or ether bond), using fluorescent probe method, polarized light microscopy and XRD. DC8+2PCs yielded myelin-figures in their dilute solutions at 25 °C, indicating that they tend to form vesicular structures rather than micelles. In contrast, DC4+1PCs lacked to form myelin-figures in their dilute solutions, being similar to short straight-chained PC surfactants, e.g., dioctanoyl-PC. The critical micelle concentrations of DCn+mPCs could be well interpreted on the basis of the total water contact surface area of the lipid hydrophobic chains, while the glycerol-linkage type seemed to have only a minor effect on the aggregation behavior of lipids.
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•Ester- and ether-type short-chained archaeal phospholipid analogs (DCn+mPCs) were developed.•DC8+2PCs form vesicles in water while DC4+1PCs form micelles in dilute aqueous solutions.•Hydrophobic surface area of chains controls the aggregation behavior of DCn+mPCs.•Difference between ester- and ether-type has only a minor effect on the aggregation behavior of DCn+mPCs. |
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ISSN: | 2215-0382 2215-0382 |
DOI: | 10.1016/j.colcom.2019.100200 |