Cranberry derived proanthocyanidins can prevent pathogen invasion of kidney epithelial cells

• Published in: Food research international Vol. 43; no. 3; pp. 922 - 924
• Main Authors: Tufenkji, Nathalie, Rifai, Omar Jandali, Harmidy, Kevin, Eydelnant, Irwin Adam
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 01.04.2010
• Subjects: Adhesion; antibacterial properties; Bacteria; bacterial adhesion; Biological and medical sciences; cell invasion; Confocal; Cranberries; dogs; Enterococcus faecalis; enteropathogens; epithelial cells; Escherichia coli; Escherichia coli O157:H7; Food industries; Food microbiology; Fruit and vegetable industries; fruit extracts; fruits (food); Fundamental and applied biological sciences. Psychology; host-pathogen relationships; kidney diseases; Kidneys; Pathogens; Proanthocyanidins; Pseudomonas aeruginosa; pyelonephritis; Vaccinium macrocarpon; Pseudomonadales; Fruit; Escherichia coli; Berry; Pseudomonas; Flavonoid; Cranberries; Invasion; Kidney; Cranberry; Infection; Polyphenol; Vaccinium; Dicotyledones; Pyelonephritis; Angiospermae; Bacteria; Pseudomonadaceae; Epithelial cell; Spermatophyta; Proanthocyanidin; Ericaceae; Enterobacteriaceae; Proanthocyanidins
• ISSN: 0963-9969; 1873-7145
• DOI: 10.1016/j.foodres.2009.10.022

The in vitro effectivity of cranberry derived proanthocyanidins (PACs) for the mitigation of kidney cell infection by selected uro- and entero-pathogens is examined with an adhesion/invasion assay and confocal microscopy. This study demonstrates that PACs effectively reduce invasion of canine kidney cells by pathogenic bacteria: Escherichia coli CFT073 and O157:H7, Enterococcus faecalis 29212, and Pseudomonas aeruginosa 10145. These effects demonstrate the potential for cranberry derived PACs as a useful tool in the prevention of kidney infection.