Combinatorial synthesis of deuterium-enriched atorvastatin

It becomes more and more difficult to discover a new drug by existing models. The concept of deuteration has gained attention due to its advantages in the study of clinical pharmacokinetics and metabolic profiles. Herein we built a library of deuterated atorvastatins using combinatorial chemistry, a...

Full description

Saved in:
Bibliographic Details
Published inMolecular diversity Vol. 20; no. 2; pp. 453 - 459
Main Authors Li, Feng, Jiang, Wenfeng, Czarnik, Anthony W., Li, Wenbao
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.05.2016
Springer Nature B.V
Subjects
Atorvastatin Calcium - chemical synthesis
Atorvastatin Calcium - chemistry
Biochemistry
Biomedical and Life Sciences
Chemical compounds
Chemical synthesis
Chemistry Techniques, Synthetic
Combinatorial Chemistry Techniques
Deuterium - chemistry
Life Sciences
Organic Chemistry
Original Article
Pharmacy
Polymer Sciences
Statins
Deuterium
Atorvastatin
Combinatorial chemistry
Deuterated derivatives
Online AccessGet full text

Cover

More Information
Summary:It becomes more and more difficult to discover a new drug by existing models. The concept of deuteration has gained attention due to its advantages in the study of clinical pharmacokinetics and metabolic profiles. Herein we built a library of deuterated atorvastatins using combinatorial chemistry, and all 16 D-compounds were characterized by 1 H NMR, 13 C NMR, MS, and elemental analysis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-015-9655-6