Discovering Nature’s super glue

Molecular glues induce novel protein–protein interactions to modulate protein function and downstream biology. A recent study unveils manumycin polyketides with multiple electrophilic centers as covalent molecular glues between UBR7 and TP53.

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Bibliographic Details
Published inNature chemical biology Vol. 16; no. 11; pp. 1155 - 1156
Main Authors Zeng, Zhi, Han, Ting
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.11.2020
Nature Publishing Group
Subjects
631/67
631/92/349
631/92/475
631/92/555
Adhesives
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Glues
News & Views
news-and-views
p53 Protein
Polyenes
Polyketides
Polyunsaturated Alkamides
Protein interaction
Proteins
Tumor Suppressor Protein p53
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More Information
Summary:Molecular glues induce novel protein–protein interactions to modulate protein function and downstream biology. A recent study unveils manumycin polyketides with multiple electrophilic centers as covalent molecular glues between UBR7 and TP53.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-020-0586-x