Synthesis and properties of amphiphilic BODIPY derivatives bearing hydroxyl groups

Functionalizable BODIPY compounds with a hydrophobic alkyl chain at the meso position and hydroxyl groups attached through alkynyl links at the 2,6 or 4,4′ positions were conveniently synthesized using Sonogashira coupling or organolithium chemistry. The compounds are readily taken up and accumulate...

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Bibliographic Details
Published inTetrahedron letters Vol. 54; no. 16; pp. 2050 - 2054
Main Authors Vincent, Matthew, Beabout, Eva, Bennett, Richard, Hewavitharanage, Priya
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 17.04.2013
Elsevier
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Summary:Functionalizable BODIPY compounds with a hydrophobic alkyl chain at the meso position and hydroxyl groups attached through alkynyl links at the 2,6 or 4,4′ positions were conveniently synthesized using Sonogashira coupling or organolithium chemistry. The compounds are readily taken up and accumulated in human osteosarcoma cells. Some compounds showed excimer formation inside cells as well as in solution.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.01.128