Effects of Neostigmine and Physostigmine on Activity of Na+,K+-ATPase in Various Subdivisions of Rat Brain

• Published in: Bulletin of experimental biology and medicine Vol. 166; no. 1; pp. 50 - 53
• Main Authors: Dubrovskii, V. N., Shalabodov, A. D., Belkin, A. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2018; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Brain - drug effects; Brain - metabolism; Cell Biology; Cerebellum; Cerebral cortex; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Fish; Internal Medicine; Intoxication; Laboratory Medicine; Male; Na+/K+-exchanging ATPase; Neostigmine; Neostigmine - pharmacology; Neostriatum; Pathology; Physostigmine; Physostigmine - pharmacology; Rats; Rats, Wistar; Rodents; Sodium-Potassium-Exchanging ATPase - metabolism; cholinoreceptor; neostigmine; physostigmine; Na + ,K + -ATPase
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-018-4287-3

The effects of intramuscular administration of neostigmine and physostigmine on Na + ,K + -ATPase activity in various cerebral subdivisions were examined in rats. In CNS and peripheral tissues, both agents rapidly and significantly reduced activity of cholinesterases by 30-50%. The development of intoxication did not change the marker indices of stress reaction. In the cerebral cortex, physostigmine increased Na + ,K + -ATPase activity, whereas neostigmine suppressed it. In addition, neostigmine decreased activity of this enzyme in the cerebellum. In contrast, both agents produced no effects on Na + ,K + -ATPase activity in the striatum. The data corroborate the view on functional interaction between Na + ,K + -ATPase and nicotinic cholinoreceptors in rat cerebral cortex.