Pulmonary non-Hodgkin’s lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis

Methotrexate is effective in treating rheumatoid arthritis (RA). Some reports have discussed the possible association between methotrexate and lymphoma. Here, we report a case of pulmonary non-Hodgkin’s lymphoma (NHL) developed after 11 years’ methotrexate therapy for RA. Biopsy of the pulmonary mas...

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Bibliographic Details
Published inRheumatology international Vol. 32; no. 11; pp. 3639 - 3642
Main Authors Wang, Huiying, Wu, Dandan, Xiang, Hua, Chen, Aifeng, Liu, Jin
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.11.2012
Springer Nature B.V
Subjects
Aged
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - pathology
Case Report
Female
Humans
Lung Neoplasms - chemically induced
Lung Neoplasms - pathology
Lymphoma, Non-Hodgkin - chemically induced
Lymphoma, Non-Hodgkin - pathology
Medicine
Medicine & Public Health
Methotrexate - adverse effects
Methotrexate - therapeutic use
Rheumatology
Rheumatoid arthritis (RA)
Non-Hodgkin’s lymphoma (NHL)
Methotrexate
Pulmonary lymphoma
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Summary:Methotrexate is effective in treating rheumatoid arthritis (RA). Some reports have discussed the possible association between methotrexate and lymphoma. Here, we report a case of pulmonary non-Hodgkin’s lymphoma (NHL) developed after 11 years’ methotrexate therapy for RA. Biopsy of the pulmonary mass demonstrated a diffuse large B-cell lymphoma. After withdrawal of methotrexate without any other intervention for 4 weeks, a significant reduction in the size of the lymphoma was observed. The causative relationship between methotrexate and pulmonary lymphoma is suggested by the persistent remission after stopping methotrexate therapy.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-010-1496-0