The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression

Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in cert...

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Bibliographic Details
Published inArchivum Immunologiae et Therapiae Experimentalis Vol. 66; no. 3; pp. 183 - 197
Main Authors Chou, Chon-Kit, Yang, Ya-Ting, Yang, Ho-Chun, Liang, Shih-Shin, Wang, Tsu-Nai, Kuo, Po-Lin, Wang, Hui-Min David, Tsai, Eing-Mei, Chiu, Chien-Chih
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.06.2018
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cancer
Chemical industry
Chemoresistance
Homeostasis
Immunology
Leaching
Nuclear receptors
Pharmacology/Toxicology
Polyvinyl chloride
Review
Tumorigenesis
Tumorigenesis
Epigenetic modifications
Nuclear receptors
DEHP
Redox homeostasis
Chemoresistance
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Summary:Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Health risks for human populations exposed to DEHP has been assumed by studies on rodents and other species, including the DEHP-induced developmental dysregulation, reproductive impairments, tumorigenesis, and diseases in a transgenerational manner. In this review, we comprehensively summarize the accumulated literature regarding the multifaceted roles of DEHP in the activation of the nuclear receptors, the alteration of the redox homeostasis, epigenetic modifications and the acquisition of chemoresistance.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0004-069X
1661-4917
DOI:10.1007/s00005-017-0494-2