The first total synthesis and structural determination of lagunamycin

Lagunamycin ( 1) has been synthesized by using our developed remote stereoinduction, Knorr condensation, periodinane oxidation, and diazonation. This enantioselective synthesis determined the absolute configuration of lagunamycin. Existence of rotational conformers was confirmed by NMR studies.

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Bibliographic Details
Published inTetrahedron letters Vol. 47; no. 35; pp. 6183 - 6186
Main Authors Hosokawa, Seijiro, Kuroda, Shoichi, Imamura, Keisuke, Tatsuta, Kuniaki
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 28.08.2006
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ANILIDES
PERIODINANE
5-LIPOXYGENASE INHIBITOR
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Summary:Lagunamycin ( 1) has been synthesized by using our developed remote stereoinduction, Knorr condensation, periodinane oxidation, and diazonation. This enantioselective synthesis determined the absolute configuration of lagunamycin. Existence of rotational conformers was confirmed by NMR studies.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.06.158