Hepatectomy and immune checkpoint inhibitor treatment for liver metastasis originating from non-cutaneous melanoma: a report of three cases

The outcomes of hepatectomy alone for liver metastasis derived from non-cutaneous melanoma are insufficient, and the outcomes of systemic therapy alone are also insufficient, even since the development of immune checkpoint inhibitors (ICIs). We report the cases of three patients, in whom liver metas...

Full description

Saved in:
Bibliographic Details
Published inInternational cancer conference journal Vol. 10; no. 4; pp. 274 - 279
Main Authors Asahi, Yoh, Kamiyama, Toshiya, Kakisaka, Tatshiko, Orimo, Tatsuya, Shimada, Shingo, Nagatsu, Akihisa, Sakamoto, Yuzuru, Ishikawa, Takaya, Kamachi, Hirofumi, Mitsuhashi, Tomoko, Takeuchi, Satoshi, Dosaka-Akita, Hirotoshi, Taketomi, Akinobu
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.10.2021
Springer Nature B.V
Subjects
Case Report
Clinical trials
Hepatectomy
Hospitals
Immune checkpoint inhibitors
Liver
Medicine
Medicine & Public Health
Melanoma
Metastases
Metastasis
Mutation
Oncology
Surgical Oncology
Thoracic surgery
Tomography
Immune checkpoint inhibitor
Liver metastasis
Melanoma
Hepatectomy
Online AccessGet full text

Cover

More Information
Summary:The outcomes of hepatectomy alone for liver metastasis derived from non-cutaneous melanoma are insufficient, and the outcomes of systemic therapy alone are also insufficient, even since the development of immune checkpoint inhibitors (ICIs). We report the cases of three patients, in whom liver metastasis derived from non-cutaneous melanoma was treated with hepatectomy combined with ICI therapy, which was administered in various settings. One patient received ICI treatment for recurrent melanoma and survived 107 months after the first hepatectomy, one patient received both preoperative and adjuvant ICI treatment and has been disease-free for 27 months, and another patient received postoperative ICI treatment after reduction hepatectomy and has been alive with disease for 47 months. Since long-term survival is possible, hepatectomy combined with ICI therapy should be considered for the treatment of liver metastasis derived from non-cutaneous melanoma.
ISSN:2192-3183
2192-3183
DOI:10.1007/s13691-021-00495-x