Anticancer Activity of Dinitrosyl Iron Complex (NO Donor) on the Multiple Myeloma Cells

The results of the study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donors) on the viability of multiple myeloma cells are presented. It was shown that DNIC7 decreased cell viability and inhibited the proliferation of multiple myeloma...

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Published inDoklady. Biochemistry and biophysics Vol. 486; no. 1; pp. 238 - 242
Main Authors Akentieva, N. P., Sanina, N. A., Prichodchenko, T. R., Gizatullin, A. R., Shkondina, N. I., Shushanov, S. S., Stupina, T. S., Aldoshin, S. M.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.05.2019
Springer Nature B.V
Subjects
Antitumor activity
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Cell proliferation
Cell viability
Cytotoxicity
Glutathione
Iron
Life Sciences
Molecular Biology
Multiple myeloma
Plasma
Reactive oxygen species
Sulfur
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Summary:The results of the study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donors) on the viability of multiple myeloma cells are presented. It was shown that DNIC7 decreased cell viability and inhibited the proliferation of multiple myeloma cells, i.e., exhibits cytotoxic properties. Fluorescent analysis showed that the DNIC7 compound decreases the level of intracellular glutathione and increases the level of reactive oxygen species in multiple myeloma cells. It is assumed that DNIC7 has a therapeutic potential for the treatment of cancer.
Bibliography:ObjectType-Article-1
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ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672919030190