ADC similarity predicts microvascular invasion of bifocal hepatocellular carcinoma

• Published in: Abdominal imaging Vol. 43; no. 9; pp. 2295 - 2302
• Main Authors: Yang, Chun, Wang, Heqing, Tang, Yibo, Rao, Shengxiang, Sheng, Ruofan, Ji, Yuan, Zeng, Mengsu
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2018; Springer Nature B.V
• Subjects: Cirrhosis; Gastroenterology; Hepatocellular carcinoma; Hepatology; Imaging; Lesions; Liver cancer; Liver cirrhosis; Magnetic resonance imaging; Medicine; Medicine & Public Health; Microvasculature; Multivariate analysis; Patients; Radiology; Regression analysis; Risk analysis; Risk factors; Similarity; Hepatocellular carcinoma; Magnetic resonance imaging; Microvascular invasion; Diffusion-weighted MRI; Apparent diffusion coefficient
• ISSN: 2366-004X; 2366-0058
• DOI: 10.1007/s00261-018-1469-4

Purpose This study aimed to investigate whether ADC similarity can predict microvascular invasion (MVI) in patients with bifocal hepatocellular carcinoma (HCC). Materials and Methods Between January 2015 and September 2015, 51 patients with two HCC lesions were included. All patients underwent conventional magnetic resonance imaging including diffusion-weighted imaging (DWI) before the HCC lesions were surgically resected; the tumor specimens were examined histopathologically. Similarity between two HCC lesions regarding DWI signal intensity (SI) and ADC value was calculated as the difference between the two lesions: Value Similarity = [1-(|value large lesion -value small lesion |)/(value large lesion  + value small lesion )] × 100%. Univariate and multivariate logistic regression analyses were performed to assess the presence of MVI. Results Risk factors significantly related to MVI of bifocal HCC in univariate analysis were cirrhosis ( P  = 0.010), histological grade ( P  = 0.040), DWI SI similarity ( P  = 0.027) and ADC similarity ( P  = 0.003). In multivariate analysis, cirrhosis (odds ratio 0.068, P  = 0.022) and ADC similarity (odds ratio 1.204, P  = 0.008) were independent risk factors for MVI of bifocal HCC. Conclusion In patients with two HCC lesions, highly similar ADC values for the two HCC lesions may be a preoperative predictor of MVI.