Fabrication of pseudo three-dimensional PADC cell culture substrates for dosimetric studies

Pseudo three-dimensional (3D) polyallyldiglycol carbonate (PADC) cell culture substrates were fabricated by creating micrometer-size pores on thin PADC films by alpha-particle irradiation and subsequent chemical etching. Our results showed comparatively fewer 53BP1 foci in alpha-particle irradiated...

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Bibliographic Details
Published inRadiation measurements Vol. 46; no. 12; pp. 1790 - 1794
Main Authors Ng, C.K.M., Wong, M.Y.P., Lam, R.K.K., Ho, J.P.Y., Yu, K.N.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Kidlington Elsevier Ltd 01.12.2011
Elsevier
Subjects
53BP1
Alpha particles
CR-39
Earth sciences
Earth, ocean, space
Exact sciences and technology
Geochronology
HeLa cells
Isotope geochemistry. Geochronology
PADC
HeLa cells
CR-39
PADC
53BP1
Alpha particles
etching
substrates
particles
carbonates
irradiation
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Summary:Pseudo three-dimensional (3D) polyallyldiglycol carbonate (PADC) cell culture substrates were fabricated by creating micrometer-size pores on thin PADC films by alpha-particle irradiation and subsequent chemical etching. Our results showed comparatively fewer 53BP1 foci in alpha-particle irradiated as well as bystander HeLa cells cultured on pseudo 3D PADC substrates than in those cultured on two-dimensional substrates.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1350-4487
1879-0925
DOI:10.1016/j.radmeas.2011.06.009