Effect of CPP-ACP on efficacy and postoperative sensitivity associated with at-home vital tooth bleaching using 20% carbamide peroxide

• Published in: Clinical oral investigations Vol. 23; no. 4; pp. 1555 - 1559
• Main Authors: Yassin, Oula, Milly, Hussam
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2019; Springer Nature B.V
• Subjects: Adolescent; Bleaching; Carbamide Peroxide; Caseins; Clinical trials; Dentin Sensitivity; Dentistry; Double-Blind Method; Female; Humans; Medicine; Original Article; Peroxide; Peroxides; Sensitivity and Specificity; Teeth; Tooth Bleaching; Tooth Bleaching Agents; Urea; Sensitivity; CPP-ACP; Bleaching; Carbamide peroxide; Colour
• ISSN: 1432-6981; 1436-3771
• DOI: 10.1007/s00784-018-2574-z

Objectives To evaluate CPP-ACP effect on colour change and tooth sensitivity (TS) associated with at-home vital tooth bleaching using 20% carbamide peroxide (CP). Methods A randomised double-blind placebo-controlled clinical trial was conducted to measure the TS and tooth colour change of 24 patients at 3-day, 7-day, 14-day and 30-day periods. The participants were instructed to apply 20% CP (7 days—04 h each) followed by the application of either CPP-ACP or non-active placebo paste, delivered by the bleaching custom tray (7 days—30 min each). Lightness (L*), redness (a*) and yellowness (b*) were measured using a digital spectrophotometer and the overall colour changes ∆ E were calculated. ∆ E and TS values were statistically analysed. The level of statistical significance was established at p  = 0.05. Results No significant differences were detected between CPP-ACP and placebo groups regarding the ∆ E . The ∆ E measurements presented significant differences within CPP-ACP groups between 3-day vs. 14-day and 30-day measurements. The CPP-ACP application reduced significantly the TS reported by the participants at 3-day when compared with the placebo group. Conclusion The application of CPP-ACP paste during at-home tooth bleaching with 20% CP was beneficial since its use reduced the TS and presented no deteriorating effect on the colour change. Clinical relevance The current findings are of importance for clinicians to manage TS reported by patients when a high CP bleaching agent is used.