Furan ring opening–pyrrole ring closure. A simple route to 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-3-ones

We report here an application of a furan ring opening-Paal–Knorr pyrrole synthesis sequence for the transformation of furfurylamines into 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-3-ones.

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Bibliographic Details
Published inTetrahedron letters Vol. 54; no. 30; pp. 3974 - 3976
Main Authors Trushkov, Igor V., Nevolina, Tatyana A., Shcherbinin, Vitaly A., Sorotskaya, Lyudmila N., Butin, Alexander V.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 24.07.2013
Elsevier
Subjects
1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazines
Chemistry
Chemistry, Organic
Furans
Physical Sciences
Recyclization
Ring closure
Ring opening
Science & Technology
1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazines
Furans
Recyclization
Ring closure
Ring opening
ENANTIOSELECTIVE SYNTHESIS
GOLD CATALYSIS
HETEROCYCLES
INHIBITORS
INDOLES
Online AccessGet full text

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More Information
Summary:We report here an application of a furan ring opening-Paal–Knorr pyrrole synthesis sequence for the transformation of furfurylamines into 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-3-ones.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.05.066