Chronic stimulation of the subthalamic nucleus increases daily on-time without dyskinesia in advanced Parkinson's disease

We assessed the efficacy of chronic stimulation of the subthalamic nucleus (STN-DBS) in 20 patients with Parkinson's disease (PD) by means of clinical assessments and patient diaries 12 months after surgery. STN-DBS reduced the UPDRS part III off-medication score by 33%, and successively improv...

Full description

Saved in:
Bibliographic Details
Published inParkinsonism & related disorders Vol. 12; no. 3; pp. 143 - 148
Main Authors Portman, A.T., Laar, T.van, Staal, M.J., Rutgers, A.W.F., Journee, H.L., Leenders, K.L.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2006
Subjects
Aged
Deep Brain Stimulation - adverse effects
Deep Brain Stimulation - methods
Dyskinesias - therapy
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neurosurgery
On-time
Parkinson Disease - therapy
Parkinson's disease
Patient diary
Patient Satisfaction
Subthalamic nucleus
Subthalamic Nucleus - physiology
Treatment Outcome
Subthalamic nucleus
On-time
Parkinson's disease
Neurosurgery
Patient diary
Online AccessGet full text

Cover

More Information
Summary:We assessed the efficacy of chronic stimulation of the subthalamic nucleus (STN-DBS) in 20 patients with Parkinson's disease (PD) by means of clinical assessments and patient diaries 12 months after surgery. STN-DBS reduced the UPDRS part III off-medication score by 33%, and successively improved complete daily on-time without dyskinesia at 12 months significantly. In conclusion, our study demonstrates the efficacy of chronic STN-DBS on motor features in a selected population of advanced PD patients. In addition to clinical assessments, patients' diaries serve as an essential tool to evaluate the functional motor status after STN-DBS.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2005.10.007