Quo Vadis, Molecular Imaging?

The important insights yielded by molecular imaging (MI) into relevant biologic signatures at an organ-specific and systemic level are not achievable with conventional imaging methods and thus provide an essential link between preclinical and clinical research. New diagnostic probes and imaging meth...

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Bibliographic Details
Published inJournal of Nuclear Medicine Vol. 61; no. 10; pp. 1428 - 1434
Main Authors Grimm, Jan, Kiessling, Fabian, Pichler, Bernd J
Format Journal Article
LanguageEnglish
Published United States Society of Nuclear Medicine 01.10.2020
Subjects
Diagnostic systems
Humans
Imaging
Luminescent Measurements
Molecular Imaging - methods
Multimodal Imaging
Probes
Radioactive tracers
radiomics
radiotracer
molecular imaging
multiparametric imaging
diagnostic probe
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Summary:The important insights yielded by molecular imaging (MI) into relevant biologic signatures at an organ-specific and systemic level are not achievable with conventional imaging methods and thus provide an essential link between preclinical and clinical research. New diagnostic probes and imaging methods revealing comprehensive functional and molecular information are being provided by MI research, several of which have found their way into clinical application. However, there are also reservations about the impact of MI and its added value over conventional, often less expensive, diagnostic imaging methods. This perspective discusses seminal research directions for the MI field that have the potential to result in added value to the patient. Emphasis is placed on MI without probes, MI based on radiotracers and small molecules, MI nano- and microsystems, and MI in context with comprehensive diagnostics. Furthermore, besides technical innovations and probes, emerging clinical indications are highlighted.
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ISSN:0161-5505
1535-5667
2159-662X
DOI:10.2967/jnumed.120.241984