Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma

Melanoma is an aggressive type of skin cancer that accounts for over 75% of skin cancer deaths despite comprising less than 5% of all skin cancers. Despite promising improvements in surgical approaches for melanoma resection, the survival of undetectable microtumor residues has remained a concern. A...

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Published inFrontiers in bioengineering and biotechnology Vol. 10; p. 947616
Main Authors Céspedes-Valenzuela, Daniela N., Sánchez-Rentería, Santiago, Cifuentes, Javier, Gómez, Saul C., Serna, Julian A., Rueda-Gensini, Laura, Ostos, Carlos, Muñoz-Camargo, Carolina, Cruz, Juan C.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 06.07.2022
Subjects
Bioengineering and Biotechnology
COMSOL multiphysics
melanoma
methacrylation
photothermal therapy
reduced graphene oxide
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Summary:Melanoma is an aggressive type of skin cancer that accounts for over 75% of skin cancer deaths despite comprising less than 5% of all skin cancers. Despite promising improvements in surgical approaches for melanoma resection, the survival of undetectable microtumor residues has remained a concern. As a result, hyperthermia- and drug-based therapies have grown as attractive techniques to target and treat cancer. In this work, we aim to develop a stimuli-responsive hydrogel based on chitosan methacrylate (ChiMA), porcine small intestine submucosa methacrylate (SISMA), and doxorubicin-functionalized reduced graphene oxide (rGO-DOX) that eliminates microtumor residues from surgically resected melanoma through the coupled effect of NIR light-induced photothermal therapy and heat-induced doxorubicin release. Furthermore, we developed an in silico model to optimize heat and mass transport and evaluate the proposed chemo/photothermal therapy in vitro over melanoma cell cultures.
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Edited by: Huacheng He, Wenzhou University, China
Jundong Shao, Shenzhen University, China
This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology
These authors have contributed equally to this work and share the first authorship
Reviewed by: Ranjith Kumar Kankala, Huaqiao University, China
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.947616