Signaling interactions predicted by the Tritope model of the TCR

As the data accumulates, it becomes obvious that the Standard Model of TCR structure-function relationships is in jeopardy. The proposed Tritope model has become more meaningful and, in any case, is richer in prediction and explanation. This is illustrated here by using the signaling interactions of...

Full description

Saved in:
Bibliographic Details
Published inImmunologic research Vol. 65; no. 5; pp. 977 - 981
Main Author Cohn, Melvin
Format Journal Article
LanguageEnglish
Published New York Springer US 01.10.2017
Springer Nature B.V
Subjects
Allergology
Animals
Antigen Presentation
Biomedical and Life Sciences
Biomedicine
Clonal Selection, Antigen-Mediated
Histocompatibility Antigens - immunology
Histocompatibility Antigens - metabolism
Humans
Immune system
Immunology
Internal Medicine
Interpretive Synthesis Review Article
Isoantigens - immunology
Mathematical models
Medicine/Public Health
Models, Immunological
Positive selection
Predictions
Receptors, Antigen, T-Cell - metabolism
Signal Transduction
Structural members
Structure-function relationships
T-Lymphocytes - immunology
Signaling
TCR
Structure-function
Online AccessGet full text

Cover

More Information
Summary:As the data accumulates, it becomes obvious that the Standard Model of TCR structure-function relationships is in jeopardy. The proposed Tritope model has become more meaningful and, in any case, is richer in prediction and explanation. This is illustrated here by using the signaling interactions of the TCR as examples. An unsuspected signaling pathway for positive selection, and for alloreactivity, is predicted. Further, crucial data needed to elucidate the structural elements that distinguish signaling for restrictive- versus allo-reactivity are identified.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-017-8941-z